Registration Dossier
Registration Dossier
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EC number: 304-802-4 | CAS number: 94279-56-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Non-guideline and non-GLP study reporting on the acute intraperitoneal toxicity of a 50% zirconyl acetate solution. Limited information on test substance and methods employed.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 950
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- zirconyl acetate
- IUPAC Name:
- zirconyl acetate
- Details on test material:
- - Name of test material (as cited in study report): zirconyl acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: adult rats
- Weight at study initiation: between 200 and 300 g
- Fasting period before study: no data
- Housing: maintained in air-conditioned rooms
- Diet (e.g. ad libitum): at libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- 50 aqueous solutions were used.
- Doses:
- Single dose, no more data
- No. of animals per sex per dose:
- 24 rats in total
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 10 days
- Statistics:
- The LD50 values were obtained from ten day mortality data by using the log-probability method.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 300 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 122 mg/kg bw
- Based on:
- element
- Remarks:
- Zr
- Mortality:
- The rats showed a progressive depression and decrease in activity until death occurred. The toxicity was considerably greater when zirconyl acetate was administered intraperitoneally (compared to the oral gavage route).
- Clinical signs:
- No characteristic physiologic changes were observed.
- Body weight:
- No characteristic physiologic changes were observed.
- Gross pathology:
- No characteristic gross pathologic changes were observed.
Applicant's summary and conclusion
- Conclusions:
- The acute LD50 value via the intraperitoneal route in rats is 300 mg/kg bw.
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