Dipotassium oxide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

other: Published data

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Justification for type of information:

Well performed study, according to OECD test guideline and compliant with GLP. Alternatively and more conveniently Potassium oxide is synthesized by heating potassium nitrate with metallic potassium: 2 KNO3 + 10 K → 6 K2O + N2 Therefore, the health effects of potassium nitrate need to be considered in the assessment of Potassium oxide

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2000

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)

GLP compliance:

yes

Test type:

up-and-down procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Potassium nitrate

EC Number:

231-818-8

EC Name:

Potassium nitrate

Cas Number:

7757-79-1

Molecular formula:

HNO3.K

IUPAC Name:

Potassium nitrate

Constituent 2

Reference substance name:

Sodium nitrate

EC Number:

231-554-3

EC Name:

Sodium nitrate

Cas Number:

7631-99-4

IUPAC Name:

sodium nitrate

Details on test material:

- Name of test material (as cited in study report): A blend of potassium nitrate and sodium nitrate.Name (IUPAC name):Potassium Sodium NitrateMolecular Formula: KNO3/NaNO3Structural Formula: KNO3/NaNO3SMILES: O(N(=O)=O)K/[Na]O(N(=O)=O)Molecular Weight: 85.0 – 101.1Alternatively and more conveniently Potassium oxide is synthesized by heating potassium nitrate with metallic potassium:2 KNO3 + 10 K → 6 K2O + N2Therefore, the health effects of potassium nitrate need to be considered in the assessment of Potassium oxide

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 60%
DOSAGE PREPARATION:
Prior to use, the test substance was ground in a coffee mill and administered by gavage as a 60% w/w suspension in distilled water (preliminary solubility testing indicated that suspensions in excess of 60% were too viscous to be administered properly).

Doses:

2000 mg/kg b.w.

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

All animals were observed for mortality, signs of gross toxicity, and behavioral changes at least once daily for 14 days after dosing. Bodyweights were recorded prior to administration and again on days 7 and 14 (termination) after dosing. Necropsies were performed on all animals at terminal sacrifice.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

All animals survived

Clinical signs:

other: All animals gained weight

Gross pathology:

No signs of toxicity were observed.

Applicant's summary and conclusion

Interpretation of results:

other: not classified

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

Acute Oral Toxicity: An LD50 value of >2000 mg/kg was obtained.
LD50 > 2000 mg/kg bw
Alternatively and more conveniently Potassium oxide is synthesized by heating potassium nitrate with metallic potassium:
2 KNO3 + 10 K → 6 K2O + N2
Therefore, the health effects of potassium nitrate need to be considered in the assessment of Potassium oxide