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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05 December 2016 to 20 January 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose:
reference to same study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2014
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Specific details on test material used for the study:
All solutions containing the test material were protected from light
Key result
Water solubility:
14.1 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
3.5
Details on results:
The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was ≤ 15 %. Based on this, the water solubility of the test material is given as the mean value of the analysed concentrations.
No test material was detected in the pre-treated sample from the blank water mixture.

Table 1: Water solubility of the test material

Stirring time (hours)

Analysed concentration (g/L)

Mean (g/L)

MD (%)

pH

24

13.8

14.1

4.4

3.5

48

14.4

3.5

72

14.2

3.5

Conclusions:
Under the conditions of this study, the water solubility of the test material at 20 °C was 14.1 g/L.
Executive summary:

The water solubility of the test material was determined in accordance with the standardised guidelines OECD 105, EU Method A.6 and US EPA OPPTS 830.7840 under GLP conditions.

Following a preliminary study, the flask method was considered to be the most appropriate.

Three aliquots between 4.53 and 4.69 g of the test material were weighed into glass vessels. To each vessel, 50 mL double distilled water was added. The vessels were placed on a magnetic stirring device at 19.7 ± 0.3 °C where the content of each vessel was stirred at 300 rpm for 24, 48 or 72 hours. As the blank, 50 mL double distilled water was stirred for 72 hours.

After the stirring period, the water phases were centrifuged. The aqueous phases were diluted with 40/60 (v/v) acetonitrile/water and analysed. The blank was diluted in a 3:2 ratio with acetonitrile and analysed.

Under the conditions of this study, the water solubility of the test material at 20 °C was 14.1 g/L. The pH of the aqueous samples was 3.5.

Description of key information

Under the conditions of this study, the water solubility of the test material at 20 °C was 14.1 g/L.

Key value for chemical safety assessment

Water solubility:
14.1 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material was determined in accordance with the standardised guidelines OECD 105, EU Method A.6 and US EPA OPPTS 830.7840 under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

Following a preliminary study, the flask method was considered to be the most appropriate.

Three aliquots between 4.53 and 4.69 g of the test material were weighed into glass vessels. To each vessel, 50 mL double distilled water was added. The vessels were placed on a magnetic stirring device at 19.7 ± 0.3 °C where the content of each vessel was stirred at 300 rpm for 24, 48 or 72 hours. As the blank, 50 mL double distilled water was stirred for 72 hours.

After the stirring period, the water phases were centrifuged. The aqueous phases were diluted with 40/60 (v/v) acetonitrile/water and analysed. The blank was diluted in a 3:2 ratio with acetonitrile and analysed.

Under the conditions of this study, the water solubility of the test material at 20 °C was 14.1 g/L. The pH of the aqueous samples was 3.5.