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EC number: 207-542-9 | CAS number: 480-16-0; 654055-01-3
Groups of 10 male and 10 female Fischer 344/DuCrj rats received 0 %, 0.625 %, 1.25 % , 2.5 % or 5.0 % (w/w) morin with dietary for 13 weeks. Especially in the higher dose groups food consumption was higher than expected, resulting in a higher than expected intake of Morin (males: 0, 299, 613, 1350, 3485 mg/kg/day; females: 0, 356, 712, 1701, 3802 mg/kg/day). No mortality in any of the tested groups was observed. Even in the highest dose group no deterioration of the general conditions could be monitored. For the male rats significant increases in ALT (over 2.5%), ALP (1.25% and 5.0%) and relative liver weights (1.25% and 2.5%) were observed. For the female rats significant increases in c-GT (over 2.5 %), AST (over 2.5 %), ALT (over 2.5 %), relative liver weights (over 2.5 %), ALP (5 %), BUN (over 1.25 %) and Cre (5.0%) were observed. The dose group0.625 % did not show any changes compared to the control group for both sexes. That concludes in the estimation of the NOEL and NOAEL at 299 and 356 mg/kg/day, respectively.
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