Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-542-9 | CAS number: 480-16-0
Groups of 10 male and 10 female Fischer 344/DuCrj rats received 0 %, 0.625 %, 1.25 % , 2.5 % or 5.0 % (w/w) morin with dietary for 13 weeks. Especially in the higher dose groups food consumption was higher than expected, resulting in a higher than expected intake of Morin (males: 0, 299, 613, 1350, 3485 mg/kg/day; females: 0, 356, 712, 1701, 3802 mg/kg/day). No mortality in any of the tested groups was observed. Even in the highest dose group no deterioration of the general conditions could be monitored. For the male rats significant increases in ALT (over 2.5%), ALP (1.25% and 5.0%) and relative liver weights (1.25% and 2.5%) were observed. For the female rats significant increases in c-GT (over 2.5 %), AST (over 2.5 %), ALT (over 2.5 %), relative liver weights (over 2.5 %), ALP (5 %), BUN (over 1.25 %) and Cre (5.0%) were observed. The dose group0.625 % did not show any changes compared to the control group for both sexes. That concludes in the estimation of the NOEL and NOAEL at 299 and 356 mg/kg/day, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again