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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Materials and methods

Principles of method if other than guideline:
ACD/Percepta model for acute oral toxicity on rat provides LD50 predictions for rats by oral administration route, based on the GALAS methodology
GLP compliance:
no
Test type:
other: in silico prediction

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenyl-2-(pyridin-2-yl)acetamide
EC Number:
230-663-3
Cas Number:
7251-52-7
Molecular formula:
C13H12N2O
IUPAC Name:
2-phenyl-2-(pyridin-2-yl)acetamide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
860 mg/kg bw
Remarks on result:
other: Moderate reliable

Any other information on results incl. tables

For 2-phenyl-2-(pyridin-2-yl)acetamide, ACD/Percepta provided an LD50 prediction equal to 860 mg/kg, and the prediction was assessed as moderate reliable being the reliability index equal to 0.71. ACD/Percepta displays up to 5 most structurally similar structures from the training set along with their experimental test results. The information on the structurally similar compounds in the training set was used to further assess the reliability of the prediction. Five compounds were identified as analogues of 2- phenyl-2-(pyridin-2-yl)acetamide. These training compounds exhibit moderate to high similarity with respect to 2-phenyl-2-(pyridin-2-yl)acetamide (similarity index ranging from 0.57 to 0.91), meaning that 2-phenyl-2- (pyridin-2-yl)acetamide is represented in the training set of the model, and experimental LD50 values ranging from 600 mg/kg (Diphenylacetic acid amide) to 2800 mg/kg (Propionamide,2-(p-isobutylphenyl)-).

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information
Conclusions:
predicted LD50 = 860 mg/kg; the prediction is assessed as moderate reliable.