Registration Dossier
Registration Dossier
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REACH
(3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-oxime
EC number: 603-883-6 | CAS number: 134931-01-4
Guidance on Safe Use
Guidance on Safe Use
Administrative data
First-aid measures
Description of first aid measures:
- General advice: Move out of contaminated area. Remove contaminated clothing immediately and dispose of safely.
- If inhaled: Move to fresh air. Make the victim blow his nose. Seek medical advice immediately.
- In case of skin contact: Rinse immediately with plenty of water for at least 15 minutes. Seek medical advice immediately.
- In case of eye contact: Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Seek medical advice immediately.
- If swallowed: Do not induce vomiting. Call emergency medical care.
Most important symptoms and effects, both acute and delayed
- Symptoms: Irritations.
- General advice: Move out of contaminated area. Remove contaminated clothing immediately and dispose of safely.
- If inhaled: Move to fresh air. Make the victim blow his nose. Seek medical advice immediately.
- In case of skin contact: Rinse immediately with plenty of water for at least 15 minutes. Seek medical advice immediately.
- In case of eye contact: Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Seek medical advice immediately.
- If swallowed: Do not induce vomiting. Call emergency medical care.
Most important symptoms and effects, both acute and delayed
- Symptoms: Irritations.
Fire-fighting measures
Extinguishing media:
- Suitable extinguishing media: all means (e.g. water, carbon dioxide, powder)
Special hazards arising from the substance or mixture:
- In case of fire, the product may emit toxic and/or irritating fumes.
- Supposed thermal decomposition/oxidation: Carbon monoxide and Carbon dioxide, Nitrogen oxides (NOx).
Advice for firefighters:
- Special protective equipment for firefighting: Use self-contained breathing apparatus.
- Further information: Avoid rejection of extinguishing water in the environment.
- Suitable extinguishing media: all means (e.g. water, carbon dioxide, powder)
Special hazards arising from the substance or mixture:
- In case of fire, the product may emit toxic and/or irritating fumes.
- Supposed thermal decomposition/oxidation: Carbon monoxide and Carbon dioxide, Nitrogen oxides (NOx).
Advice for firefighters:
- Special protective equipment for firefighting: Use self-contained breathing apparatus.
- Further information: Avoid rejection of extinguishing water in the environment.
Accidental release measures
Personal precautions, protective equipment and emergency procedures:
Half mask filtering particles, particle filter P3. Gloves. Safety goggles. Work clothes.
Environmental precautions:
Avoid any spreading of product.
Methods and materials for containment and cleaning up:
- General advice: Sweep and shovel the solid product in an adapted container for its recovery or destroying (avoiding dust formation). Close and label rigorously.
- Cleaning of contaminated zone: After taking up the product, rinse the polluted area with water.
- Elimination of recovered materials: Deliver to Environmental service of the factory or to any specializedand approved disposal service.
Additional advice:
Intervention of special services recommended.
Half mask filtering particles, particle filter P3. Gloves. Safety goggles. Work clothes.
Environmental precautions:
Avoid any spreading of product.
Methods and materials for containment and cleaning up:
- General advice: Sweep and shovel the solid product in an adapted container for its recovery or destroying (avoiding dust formation). Close and label rigorously.
- Cleaning of contaminated zone: After taking up the product, rinse the polluted area with water.
- Elimination of recovered materials: Deliver to Environmental service of the factory or to any specializedand approved disposal service.
Additional advice:
Intervention of special services recommended.
Handling and storage
Precautions for safe handling:
-Precaution on safe handling (industrial scale): Ventilation and extraction of dust at emission point. Take precautionary measures against electrostatic loading. Earth vessels and equipment.
- Advice on safe handling (laboratory scale): Handling in a fume cupboard.
Conditions for safe storage, including any incompatibilities:
- Requirements for storage rooms and vessels: Keep in a cool, well-ventilated place.
- Advice on common storage: Do not store with strong oxidizing agents.
- Further information on storage conditions: Keep in a well closed container, away from moisture and light.
- Storage temperature: Keep away from heat.
- Packaging material advised: Glass, polyethylene.
- Packaging provided by the supplier: Was cardboard with plastic bag
- Sensitivity: humidity: weakly hygroscopic
-Precaution on safe handling (industrial scale): Ventilation and extraction of dust at emission point. Take precautionary measures against electrostatic loading. Earth vessels and equipment.
- Advice on safe handling (laboratory scale): Handling in a fume cupboard.
Conditions for safe storage, including any incompatibilities:
- Requirements for storage rooms and vessels: Keep in a cool, well-ventilated place.
- Advice on common storage: Do not store with strong oxidizing agents.
- Further information on storage conditions: Keep in a well closed container, away from moisture and light.
- Storage temperature: Keep away from heat.
- Packaging material advised: Glass, polyethylene.
- Packaging provided by the supplier: Was cardboard with plastic bag
- Sensitivity: humidity: weakly hygroscopic
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
Personal protective equipment
(IMPORTANT: The equipments listed below are recommended in case of important potential exposure. In case of moderate exposure, they are to be adapted according to the risk assessment at the workplace.)
Workshop
- Respiratory protection: P3 dust half-mask recommended.
- Hand protection: Doubled gloves recommended. Glove material: Nitrile rubber ; Layer thickness: 0,11 mm ; Break through time: > 480 min.
- Eye protection: Safety goggles.
- Body protection: Work clothes.
- Hygiene measures: wash hands.
Laboratory
- Respiratory protection: Handle in a fume cupboard.
- Hand protection: Suitable gloves.
- Eye protection: Safety goggles.
- Body protection: Work clothes.
- Hygiene measures: Wash hands.
(IMPORTANT: The equipments listed below are recommended in case of important potential exposure. In case of moderate exposure, they are to be adapted according to the risk assessment at the workplace.)
Workshop
- Respiratory protection: P3 dust half-mask recommended.
- Hand protection: Doubled gloves recommended. Glove material: Nitrile rubber ; Layer thickness: 0,11 mm ; Break through time: > 480 min.
- Eye protection: Safety goggles.
- Body protection: Work clothes.
- Hygiene measures: wash hands.
Laboratory
- Respiratory protection: Handle in a fume cupboard.
- Hand protection: Suitable gloves.
- Eye protection: Safety goggles.
- Body protection: Work clothes.
- Hygiene measures: Wash hands.
Stability and reactivity
Stability and reactivity
Safety remarks: Risk of dust explosion (no available data)
Incompatible materials:
Strong oxidizing agents
Hazardous decomposition products:
Supposed thermal decomposition/oxidation: carbon dioxide and carbon oxide, and nitrogen oxides (NOx).
Safety remarks: Risk of dust explosion (no available data)
Incompatible materials:
Strong oxidizing agents
Hazardous decomposition products:
Supposed thermal decomposition/oxidation: carbon dioxide and carbon oxide, and nitrogen oxides (NOx).
Disposal considerations
Product: Deliver to the Environmental service of the factory or to any specialized and approved disposal service.
Uncleaned packaging: Deliver to the Environmental service of the factory or to any specialized and approved disposal service.
Uncleaned packaging: Deliver to the Environmental service of the factory or to any specialized and approved disposal service.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
