Registration Dossier
Registration Dossier
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EC number: 229-388-1 | CAS number: 6505-28-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No effects on fertility or offspring development were observed in a screening study with rats (OECD 421) performed with doses of up to 1000 mg/kg bw.
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Screening study (OECD 421)
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Screening study (OECD 421)
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available screening study is reliable and suitable for classification purposes under Regulation 1272/2008. No adverse effects were noted at the limit dose of 1000 mg/kg bw. As a result the substance is not considered to be classified for fertility or developmental toxicity under Regulation (EC) No. 1272/2008,as amended for the seventh time in Regulation (EC) No 2015/1221.
During the four days covered in the screening study, no effects via lactation were observed.
Additional information
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