2-(1-(3',3'-dimethyl-1'-cyclohexyl)ethoxy)-2-methyl propyl propanoate

Surface tension

Link to relevant study record(s)

Reference

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1995-02-20 to 1995-07-15

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. However, the 90% saturation level was not achieved. Substance identification is specified with purity, but isomers composition is missing. Therefore restrictions apply to the result itself, but the study is considered sufficiently reliable for qualitative assessment.

Reason / purpose for cross-reference:

reference to other study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Qualifier:

according to guideline

Guideline:

other: ISO 304

GLP compliance:

yes (incl. QA statement)

Remarks:

UK GLP compliance programme (inspected on 31 January 1994 / signed on 16 March 1994)

Type of method:

ring method

Specific details on test material used for the study:

Storage conditions: metal bottle at room temperature.

Surface tension:

62.4 mN/m

Temp.:

18.5 °C

Conc.:

3.91 mg/L

The peak areas relating to the standards and sample solutions are shown below:

Solution	Mean peak area
Standard 99.4 mg/L	5.676 x 10^4
Standard 105 mg/L	6.147 x 10^4
Sample A	5.554 x 10^4
Sample B	5.727 x 10^4

Mean sample solution concentration = 3.91 mg/L

Calibration

Reading (mN/m)	Temperature (°C)	Literature value	Calibration factor
73.0	18.5	72.98	1.000
72.9	18.5		1.001
73.0	18.5		1.000
73.1	18.5		0.998
72.9	18.5		1.001
73.3	18.5		0.996

Mean calibration factor = 0.999

Sample solution

Time (mins)	Reading (mN/m)	Temperature (°C)
133	62.4	18.5
145	62.4	18.5
160	62.5	18.5
193	62.5	18.5
209	62.5	18.5
239	62.3	18.5

Mean reading = 62.4 mN/m

Surface tension = reading x calibration factor = 62.4 x 0.999 = 62.4 mN/m

Conclusions:

According to EU A5 criteria, as the result is above the threshold value of 60 mN/m, the substance is NOT considered to have surface-active potential under the experimental conditions.

Executive summary:

The surface tension of the test substance was measured under GLP according to ISO 304 (listed in EU A5 guideline), ring method.

Six measurements were performed on a single solution at 3.9 mg/L, corresponding to about 83% of the saturation solubility, and 18.5°C. No time dependency was observed, and the mean value was corrected with calibration factor from water.

The surface tension of the test substance is 62.4 mN/m, at 3.9 mg/L and 18.5°C.

Description of key information

62.4 mN/m at 3.9 mg/L (ca 83% saturation). Not surface-active under testing conditions.

Additional information

An experimental study is available, however testing conditions do not comply with the requirements of the guideline. The result is nevertheless considered as sufficiently reliable for qualitative information (as close to the required concentration), but cannot be retained as key value for purpose of CSA.