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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1984
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Justification for type of information:
The main structure of the read-across substance is the same of the CJ304, only the salt form is different. However, this difference does not influence the toxicity of the CJ304. CJ304 contains Li/Na salt form and the read-across substances contains only Na salt. This will not lead to difference on the toxicity results.
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Version / remarks:
Comparable to internationally accepted guidelines.
GLP compliance:
no
Specific details on test material used for the study:
Name: FAT 41001/D
Purity: 78.8 %
Analytical monitoring:
no
Vehicle:
not specified
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
TEST ORGANISM
- Common name: Zebra fish
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Test temperature:
25 °C
pH:
8 - 8.2
Dissolved oxygen:
7.7 - 7.8
Nominal and measured concentrations:
100, 300 and 1000 mg/L
Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
100 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
143.12 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
300 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Details on results:
After 48h: 10/10, 0/10, 0/10 fishes survived at 100 mg/L, 300 mg/L and 1000 mg/L respectively.
After 96h: 10/10, 0/10, 0/10 fishes survived at 100 mg/L, 300 mg/L and 1000 mg/L respectively.
Validity criteria fulfilled:
not specified
Conclusions:
The 96h LC50 of FAT 41001/D in this fish acute toxicity test was determined to be 143.12 mg/L.
Executive summary:

The acute fish toxicity test of FAT 41001/D was performed using a methodology equivalent or similar to OECD Guideline 203. 10 Zebra fish per concentration were exposed to FAT 41001/D for 96 hours at following concentrations: 100, 300 and 1000 mg/L.

After 48h: 10/10, 0/10, 0/10 fishes survived at 100 mg/L, 300 mg/L and 1000 mg/L respectively.

After 96h: 10/10, 0/10, 0/10 fishes survived at 100 mg/L, 300 mg/L and 1000 mg/L respectively.

Based on these findings, the 96h LC50 of FAT 41001/D in this fish acute toxicity test was determined to be 143.12 mg/L.

Summary;

LC0 (48 h) : 100 mg/L

LC50 (48 h) : 181.5 mg/L

LC100 (48 h) : 300 mg/L

LC0 (96 h) : 100 mg/L

LC50 (96 h) : 143.12 mg/L

LC100 (96 h) : 300 mg/L

Description of key information

The 96h LC50 of FAT 41001/D in this fish acute toxicity test was determined to be 143.12 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
143.12 mg/L

Additional information