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EC number: 246-430-4
CAS number: 24720-09-0
of the test item in test water: Concentrations of the test item were
maintained at more than 78% of nominal concentrations. The variation of
the concentrations of the test item was within± 20% of the average of
the measured concentrations.
5.3.1/1: Measured concentrations of test item in test water
After 3 days
After 6 days
After 12 days
After 19 days
After 24 days
After 28 days
Average (Standard deviation)
5.3.1/2: Measured concentrations of test item in test fish (ng/g)
5.3.1/3: BCFs = Cf / Cw
5.3.1/4: Variation of BCFs (the values are indicated for five figures)
Average of three results
The average BCF
Variation rate from the average of three results (%)
the variation of BCFs (average value) for the last three successive
analyses was over ± 20%, the BCFss could not be calculated. However, it
was evaluated that a steady-state was reached after 28 days because all
BCFs were less than 100.
bioaccumulation study was performed according to the OECD Guideline No.
305. The study was carried out to determine the extent of accumulation
of test item by the carp, Cyprinus carpio during the exposure
period of 28 days.
exposure levels: Level 1: 5 µg/L; Level 2: 0.5 µg/L.
was performed at 24.0-25.0 °C and dissolved oxygen was 7.2 - 8.3 mg/L.
Analyses of test water and fish were conducted on Days 3, 6, 12, 19, 24
and 28 after exposure using gas
chromatography-mass spectrometry (GC-MS). Bioconcentration
factor (BCF) was calculated.
of test substance in test water:
concentration during the test period were as follows
Level 2: 0.420±0.0217
factors: BCFs of the test item were 8.4 - 20 at Level 1 and 8.4 - 20 at
Level 2. No abnormality in behavior or appearance was noted.
to the results of the bioconcentration test, it was confirmed that the
steady state in both concentration levels was achieved on the 28th day
of exposure. The bioconcentration factors (BCFs) were 8.4 - 20 at Level
1 and 8.4 - 20 at Level 2.
OECD Guideline 305, GLP, key study,
BCF = 8.4 to 20
To assess the bioaccumulation potential of
the registered substance, one key study is available. This study was
to the OECD Guideline 305 with GLP statement in oder to determine the
extent of accumulation of registered substance by the carp, Cyprinus
carpio, during the exposure period of 28 days. Two nominal exposure
levels of the test substance were used (5 µg/L for the Level 1 and 0.5
µg/L for the Level 2, corresponding to mean measured concentrations of
4.68 +/- 0.189 µg/L and 0.420 +/- 0.0217 µg/L, respectively).
of test water and fish were conducted on Days 3, 6, 12, 19, 24 and 28
after exposure using gas
chromatography-mass spectrometry (GC-MS) and the Bioconcentration
factor (BCF) were calculate.
According to the results of this study, it was confirmed that the steady
state in both concentration levels was achieved on the 28th day of
exposure and the BCFs of the test substance were comprised between 8.4
and 20 for both concentration levels (same result). No abnormality in
behavior or appearance was noted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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