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Melting point / freezing point

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melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
June 16, 2004
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
The study was conducted according to OECD/EU guideline, and under GLP. No deviation was reported. The substance is adequately characterised. Therefore full validation applies.
according to guideline
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
according to guideline
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
Directive 92/69/EEC (which constitutes Annex V of Directive 67/548/EEC)
according to guideline
other: Method for the Determination of Crystallizing Point (BS4633)
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Swiss GLP compliance programme (inspected on September 09 and 30, 2002/ signed on December 2002)
Type of method:
method to determine freezing temperature
Specific details on test material used for the study:
Storage condition of test material: Refrigerator (between 0 and 10 °C under nitrogen)
Key result
Melting / freezing pt.:
4 °C

The test material remained unchanged until 265 K, then a crystal of test material was added to the supercooled liquid to initiate the crystallization and the test tube was removed from the cold bath and allowed to warm at room temperature.

Determination 1: 277 K

Determination 2: 277 K

accuracy ± 0.5 °C; 277 ± 0.5 K

Executive summary:

The freezing point of the test substance was determined according to OECD 102/EU A1 guideline using BS4633 method for the determination of crystallizing point.

The determination was carried out in duplicate, and the mean final temperature was retained.

The freezing temperature of test substance has been determined to be 4 °C (277 K), with initiation.

Description of key information

Freezing point = 4°C with initiation; no freezing observed down to -6°C without initiation.

The substance can be stable in supercooling conditions.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
4 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as a key study, and the result is retained as key value for purpose of CSA.