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EC number: 218-500-4 | CAS number: 2164-17-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
1. - Acute (one single dose) study oral (gavage), rat m/f, (EPA FIFRA, Subdivision F, §81-1 (1984) = EEC B.1 (1992): LD50 > 5000 mg/kg bodyweight.
2. - Acute (single 4 hour exposure) study inhalation, rat m/f, EPA FIFRA, Subdivision F, §81-3 (1984) = EEC B.2 (1992): LC50 > 4.62 mg/l (technical limit)
3. - Acute (one single application) study dermal, rabbit m/f, EPA FIFRA, Subdivision F, §81-2 (1984) = EEC B.3 (1992): LD50 > 2000 mg/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Acute toxicity, local tolerance
Fluometuron is of low acute toxicity irrespective of the route of exposure (oral, dermal or inhalation) with LD50/LC50 values in excess of the international regulatory limit dose (See Table below). At the highest oral limit dose all animals initially showed lethargy and hunched posture recovery was complete within the first day, thereafter there were no clinical signs of reaction to treatment. No evidence of systemic toxicity or skin irritation was seen after a single dermal exposure of rats to 2000 mg/kg. Acute inhalation exposure caused non-specific signs typical of exposure to a high concentration of dust particles and method of restraint (wet fur and decreased respiratory rate). After exposure, hunched posture, decreased respiratory rate, lethargy and pilo-erection were recorded. All animals appeared normal two days after treatment and for the rest of the study period, no deaths were recorded.
Table 7.2 : Summary of acute toxicity of fluometuron
Parameter |
Species |
Result |
Reference |
Acute oral (LD50) |
Rat |
> 5000 mg/kg |
Jones, 1989a |
Percutaneous (LD50) |
Rabbit |
> 2000 mg/kg |
Jones, 1989b |
Acute inhalation (LC50) |
Rat |
> 4.62 mg/l |
Jones, 1989c |
Justification for classification or non-classification
In accordance with regulation 1272/2008, Annex I, 3.1, classification for acute toxicity is not required.
Within all tests LD50 values requiring classification were not reached. For inhalation concentration of Fluometuron was technically limited to 4.62 mg/L. As no deaths from inhalation up to the limit and also for oral administration at 5000 mg/kg bodyweight were observed, no deaths in the range between 4.62 and 5 mg/L are expected.
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