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EC number: 203-273-6 | CAS number: 105-13-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 October 2015 and 11 January 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 2001
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- p-methoxybenzyl acetate
- EC Number:
- 203-185-8
- EC Name:
- p-methoxybenzyl acetate
- Cas Number:
- 104-21-2
- Molecular formula:
- C10H12O3
- IUPAC Name:
- 4-methoxybenzyl acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Orientbio Inc., Republic of Korea
- Age at study initiation: 8 weeks old
- Weight at study initiation: 181.5 - 198.2 g
- Fasting period before study: yes, overnight
- Housing: individually (during the study)
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21.2 - 23.4
- Humidity (%): 48.6 - 55.2
- Air changes (per hr): 10 - 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 400 mg/mL
MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg
CLASS METHOD
- Rationale for the selection of the starting dose: Due to expected low toxicity of the test substance, 2000 mg/kg was selected as the starting dose. - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 (divided in two groups for step 1 and step 2)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: prior to dosing on day 0 and on days 1, 3, 7 and on the day of necropsy, day 14
- Frequency of observations (mortality, general conditions and clinical signs): at 30 min after dosing and at 1, 2, 4 and 6 hours after dosing on day 0 and once thereafter for 14 days (day 1 to day 14)
- Necropsy of survivors performed: yes (complete gross postmortem examinations were performed on all animals) - Statistics:
- Statistical analysis was not performed. Mean scores and values are determined.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50 cut-off
- Effect level:
- >= 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- Decrease of fecal volume was evident in one animal at 2000 mg/kg bw on day 1 after dosing, and then it normalized on day 2 afte dosing. Therefore, it was considered to be a test substance-related temporary change.
- Body weight:
- A tendency to suppressed body weight gain was evident in all animals at 2000 mg/kg bw on day 1 after dosing. Then, these animals returned to be normal on day 3. These changes were considered to be test substance-related effects.
- Gross pathology:
- No grossly visible evidence of morphological abnormalities was evident in any animal at 2000 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of the acute oral toxicity study in rats, the LD (cut off) value was determined to be greater or equal than 5000 mg/kg bw.
- Executive summary:
The acute oral toxicity of the test substance analogue was examined in a GLP-conform study according to OECD 423. A single oral dose of the test substance analogue was administered to two groups of three female Sprague-Dawley rats. In the first step, a dose 2000 mg/kg bw was administered to the first group and no mortality was observed. In the second step, the same dose was administered to group 2. All animals were monitored for clinical signs and body weight changes during 14 -day observation period after administration. They were subjected to a gross necropsy at the end of the observation period. There were no deaths of animals at 2000 mg/kg bw. Decrease of fecal volume was evident in one animal at 2000 mg/kg bw on day 1 after dosing, and then it normalized on day 3. No substance-related effects were evident in any animal at 2000 mg/kg bw. Based on the results of the acute oral toxicity study in rats, the LD (cut off) value was determined to be greater or equal than 5000 mg/kg bw.
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