Registration Dossier
Registration Dossier
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EC number: 284-635-0 | CAS number: 84961-46-6 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cinnamomum cassia, Lauraceae.
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Gene mutation in bacteria (OECD 471): Negative
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
The genotoxicity of the test substance Cassia oil was tested according to OECD TG 471 (Ames test) and under GLP conditions. No significant increases in the frequency of revertant colonies were recorded for any of the bacterial strains, with any dose of the test item, either with or without metabolic activation or exposure method. Based on the results of this Ames test, the test item Cassia oil was considered to be non-mutagenic under the conditions as specified.
Justification for classification or non-classification
Based on the results of the Ames test, the substance is not mutagenic and therefore it does not have to be classified for mutagenicity in accordance with the criteria outlined in Annex I of 1272/2008/EC (CLP/EU-GHS).
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