Registration Dossier
Registration Dossier
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EC number: 210-276-6 | CAS number: 611-71-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP Guideline Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- L-2-hydroxy-2-phenylacetic acid
- EC Number:
- 210-276-6
- EC Name:
- L-2-hydroxy-2-phenylacetic acid
- Cas Number:
- 611-71-2
- Molecular formula:
- C8H8O3
- IUPAC Name:
- hydroxy(phenyl)acetic acid
- Details on test material:
- - Name of test material (as cited in study report): D-(-)-Mandelsaeure
no further data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Germany
- Weight at study initiation: 2.00-2.14 kg
- Housing: individually
- Diet: ca. 130 g/animal/day
- Water: ca. 250 ml/animal/day
- Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24 °C
- Humidity (%): 30-70 %
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eyes of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml - Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- 24 hours, study was discontinued due to severe effects on the eyes
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM: according to OECD guidelines 405
TOOL USED TO ASSESS SCORE: light
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 4
- Reversibility:
- not fully reversible within: 24 hours
- Remarks on result:
- other: The study was discontinued after 24 hours because of severe irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 hours
- Remarks on result:
- other: iris score could not be read due to severe corneal opacity
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 2
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 2
- Reversibility:
- not fully reversible within: 24 hours
Any other information on results incl. tables
Due to the severe eye irritation observed, the study was discontinued after 24 hours. The test substance is there for classified as posing the risk of serious eye damage (R41) according to EU- and as eye irritant Cat.1 according to GHS-criteria.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Migrated information
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