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Diss Factsheets
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EC number: 203-104-6 | CAS number: 103-36-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There are no chronic test results available. However, acute toxicity tests for the 3 trophic levels are available.
For the acute toxicity towards fish there is one study available according to the OECD guideline 203 under semi-static conditions. During 96 hours 7 test organisms were exposed to 0.529 - 1.07 - 2.27 - 4.55 - 9.58 mg/L (geometric mean measured concentrations). The LC50 after 96 hours was 3.21 mg test item/L.
In an OECD 202 study under static conditions over a duration of 48 hours the acute toxicity of the test item to Daphnia magna was evaluated. The test concentrations were 88.4, 46.5, 21.9, 10.2 and 4.42 mg/L (measured concentrations).
After 48 hours the EC50 was 12.1 mg/L.
For the toxicity to algae a publication is available in which the effects of the test item on the growth and physiological characteristics of Chlorella pyrenoidosa were assessed. The test organisms were exposed to 2.0, 4.0, 8.0 and 10.0 mg/L (nominal concentrations). Although the test concentrations were not analytically verified, the exposure concentrations were stable during the test as both effects based on inhibition of the growth rate and the level of chlorophyll tend to increase with increasing concentration levels and exposure time. The EC50 at 96 h was determined to be 5.45 mg/L.
Additionally, read-across was done from the source substane methyl cinnamate. On this source substance a study with Pseudokirchneriella subcapitata was performed in accordance with OECD guideline 201 and EU guideline C.3. In this study, significant inhibitory effect on the growth rate and yield of the algae after 48 and 72h was observed, yielding a 72h ErC50 of 7.6 mg/L and a 72h ErC10 of 4.0 mg/L. Based on these results, and on the structural, chemical and toxicological similarities between the source and target substance, the 72h ErC50 for algae in the target substance ethyl cinnamate is calculated to be 8.26 mg/L and the ErC10 is 5.00 mg/L, taking into account the difference in molecular weight between source and target substance.
In conclusion, based on the available information, it can be assumed that fish are the most sensitive species and therefore an LC50 of 3.21 mg/L is used in the hazard assessment and derivation of aquatic PNECs.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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