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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only secondary literature

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute 9-day and 13-week inhalation studies of ethylene glycol monohexylether
Author:
Klonne, DR et al.
Year:
1987
Bibliographic source:
Fundam. Appl. Toxicol. 8: 198-206
Reference Type:
publication
Title:
No information
Author:
Klonne, DR et al.
Year:
1986
Bibliographic source:
The Toxicologist 6 (1), 60, Abstract No. 237
Reference Type:
secondary source
Title:
Unnamed
Year:
2005

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Hexylglycol (EGHE)
IUPAC Name:
Hexylglycol (EGHE)
Constituent 2
Chemical structure
Reference substance name:
2-hexyloxyethanol
EC Number:
203-951-1
EC Name:
2-hexyloxyethanol
Cas Number:
112-25-4
Molecular formula:
C8H18O2
IUPAC Name:
2-(hexyloxy)ethanol

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation
Duration of exposure:
4 h
Concentrations:
83 ppm

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
> 0.5 mg/L air
Exp. duration:
4 h

Applicant's summary and conclusion

Executive summary:

Hexylglycol is the parent compound and occurs together with the sodium salt of the submission substance identity. For systemic toxicity, the glycol ether is regarded as a worst case as it is a good solvent and most probably taken up in higher percentages than the ionic salt.

Testing of this specific endpoint is additionally advised against for the submission substance because of its corrosive properties.