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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comprehension of case reports.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
The value of corneal peeling or corneal resection in ophthalmology.
Author:
Kilgore, G. L.
Year:
1946
Bibliographic source:
Trans Am Ophthalmol Soc. 44:100-112

Materials and methods

Type of study / information:
Case report
Endpoint addressed:
eye irritation
Principles of method if other than guideline:
The use of quinine bisulphate ointment, 2 %, for several years as a clarifier of corneal opacities is described in two case reports.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): quinine bisulphate

Method

Ethical approval:
not applicable
Details on study design:
Case 1- Sex: male- Age: 33- History: Quicklime was splashed in both eyes when he was seven years of age.- Symptoms, onset and progress of the disease: Vision of right eye is 20/200, left eye 5/200- Other: A corneal resection was performed on the right eye, with removal of a horizontal band of scar tissue four mm wide and one-half mm thick from in front of the pupil. A similar horizontal band of scar tissue four mm wide and one-half mm thick was removed from the corneal surface of the left eye. Quinine bisulphate ointment (2 %) was used in each eye for a short timeCase 2- Sex: male - Age: 40- History: Patient had a gonococcal infection of each eye with ulceration of the cornea of each eye and loss of left globe from panophthalmitis. - Other: A corneal peeling operation was done under cocaine anaesthesia. A cross incision was made in the cornea to a depth of three-quarters mm followed by dissecting the four quadrants free and off. There was a small break in the epithelial covering near the centre of the cornea. Quinine bisulphate ointment (2%) were prescribed for use twice a day.
Exposure assessment:
measured

Results and discussion

Results:
Quinine bisulphate ointment has been used for a number of years as a clarifier of corneal opacities through its destruction of lymphocytes and leukocytes. Therefore, a 2 % quinine bisulphate ointment was used post-operative to improve the regeneration. Thus, we conclude that quinine is not irritating to eyes.

Applicant's summary and conclusion

Conclusions:
Quinine bisulphate ointment has been used for a number of years as a clarifier of corneal opacities. Therefore, in the two case reports a 2 % quinine bisulphate ointment was used post-operative to improve the regeneration. Thus, we conclude that quinine is not irritating to eyes.
Executive summary:

Quinine bisulphate ointment has been used for a number of years as a clarifier of corneal opacities through its destruction of lymphocytes and leukocytes. Therefore, in the two case reports a 2 % quinine bisulphate ointment was used post-operative to improve the regeneration. Thus, we conclude that quinine is not irritating to eyes and quinidine which is a stereoisomer of quinine is not irritating to eyes, too.