Registration Dossier
Registration Dossier
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EC number: 943-043-9 | CAS number: 8015-91-6
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 = 3458 mg/kg bw (similar to OECD401)
Acute dermal toxicity: LD50 = 702 mg/kg bw (similar to OECD402)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 458 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 702 mg/kg bw
Additional information
Acute oral toxicity
The study was performed according to a method similar to OECD 401. 25 Sherman Wistar (albino) rats (15 male, 10 female) were dosed with varying doses of cinnamon bark oil via oral gavage. Test groups were administered with doses that ranged from 2034 to 5086 mg/kg bw, with 5 rats in each group (3 male, 2 female). Rats were observed for 14 days after treatment. No mortality was observed in the two lowest dose groups (2034 and 2543 mg/kg bw). Three out of 5 rats died at 3214 and 4069 mg/kg bw, while all rats died in the highest dose group (5086 mg/kg bw). All deaths occurred within 1 day after exposure. Based on these results a LD50 of 3458 mg/kg bw was calculated.
Acute dermal toxicity
Acute dermal toxicity was determined according to a method similar to the OECD 402 guideline. Twenty albino rabbits (10 with abraded, 10 with intact skin, 2x2 rabbits per dose group) were exposed to 321, 455, 641, 905 or 1282 mg/kg bw cinnamon bark oil. Rabbits were observed for 14 days after treatment. No mortality was observed in the three lowest dose groups with intact skin (321, 455 and 641 mg/kg bw). Mortality occurred within 4 days after exposure in all rabbits in the 905 and 1282 mg/kg bw dose groups. Based on these results an LD50 of 702 mg/kg bw was calculated.
Justification for classification or non-classification
Based on the available information, the substance does not need to be classified for acute oral toxicity in accordance with the criteria outlined in Annex I of 1272/2008/EC (CLP/EU-GHS).
Based on the available information, the substance needs to be classified for acute dermal toxicity (Category 3 / H311) according to the criteria outlined in Annex I of 1272/2008/EC (CLP/EU-GHS).
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