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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
carcinogenicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Carcinogenic and Toxicological Effects of Inhaled Ethylene Oxide and Propylene Oxide in F344 Rats.
Author:
Lynch, D.W., T.R. Lewis, W.J. Moorman, J.R. Burg, D.H. Groth, A. Khan, L.J. Ackerman and B.Y. Cockerell
Year:
1984
Bibliographic source:
Toxicol. Appl. Pharmacol. 76: 69-84

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 451 (Carcinogenicity Studies)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyloxirane
EC Number:
200-879-2
EC Name:
Methyloxirane
Cas Number:
75-56-9
Molecular formula:
C3H6O
IUPAC Name:
2-methyloxirane

Test animals

Species:
rat
Sex:
not specified

Administration / exposure

Route of administration:
inhalation

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Description (incidence and severity):
Mammary
Mortality:
mortality observed, treatment-related
Description (incidence):
Mammary

Effect levels

Dose descriptor:
LOAEL
Effect level:
300 ppm
Based on:
other: air concentration
Remarks on result:
other: Effect type: carcinogenicity (migrated information)

Applicant's summary and conclusion