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EC number: 211-902-0 | CAS number: 708-06-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984 - 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed OECD study woith GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-hydroxy-1-naphthaldehyde
- EC Number:
- 211-902-0
- EC Name:
- 2-hydroxy-1-naphthaldehyde
- Cas Number:
- 708-06-5
- Molecular formula:
- C11H8O2
- IUPAC Name:
- 2-hydroxynaphthalene-1-carbaldehyde
- Details on test material:
- Purity: 94%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Hoe: WISKf (SPF71)
- Source: HOECHST AG, Kastengrund, SPF-Zucht
- Weight at study initiation: males: 204+-9.62 g; females: 174,1+-6.62 g
- Fasting period before study: 16 hours
- Housing: in completely air conditioned rooms in macrolon cages in groups of 5 animals
- Diet: Rattendiat Altromin 1324 (ad libitum):
- Water: tap water from plasic bottles (ad libitum):
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+-3
- Humidity (%): 50+-20
- Photoperiod: 12 hours daily
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- concentration in vehicle: 25% (w/w)
- Doses:
- see below
- No. of animals per sex per dose:
- 5 females: dose: 4000 mg/kg bw, application volume: 16 ml/kg bw
5 males and 5 females: dose: 5000 mg/kg bw, application volume: 20 ml/kg bw - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily and weighing: once per week
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ observation
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 - < 5 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- During the 14-days observation period
after application of 5000 mg/kg bw (5 males and 5 females) one male and four females died
after application of 4000 mg/kg bw ( 5 females) one female died - Clinical signs:
- other: Squatting posture, decreased spontaneous activity, prone position, flanks pinched in, irregular respiration, diarrhoe. One day after application no more respiration depression but cat bristling pale and yellow skin, dark yellow urine from day 6 after appl
- Gross pathology:
- section of the animals that died during the observation period:
content of stomach and intestine was yellow to orange yellow
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 (female rats): 4000 - 5000 mg/kg bw
LD50 (male rats): > 5000 mg/kg bw - Executive summary:
The substance was tested for acute oral toxicity according to OECD guideline 401. 5 male and 5 female Wistar rats were administered a dose of 5000 mg/kg bw and 5 female Wistar rats a dose of 4000 mg/kg bw.During the 14 days observation period after the application one male and four female animals from the 5000 mg/kg bw - group died and one female out of the 4000 mg/kg bw - group.
The LD50 for female rats is therefore between 4000 and 5000 mg/kg bw and for male rats greater than 5000 mg/kg bw.
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