4-[(4-chloro-6-{[(3 or 4)-sulfophenyl]amino}-1,3,5-triazin-2-yl)amino]-2-{[1-ethyl-2-hydroxy-4-methyl-6-oxo-5-(sulfonatomethyl)-1,6-dihydropyridin-3-yl]diazenyl}benzenesulfonic acid, lithium sodium salts

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1989-06-02

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Justification for type of information:

The structure of the read-across substance is the para form of the CJ301 without the meta form. However, this difference does not influence the toxicity of the CJ301. CJ301 contains Li/Na salt form and the read-across substances contains only Na salt. This will not lead to difference on the toxicity results.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1989

Report date:

1989

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method B.3 (Acute Toxicity (Dermal))

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

1981

GLP compliance:

yes

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Potassium sodium 5-(5-(4-chloro-6-(4-sulfonatophenylamino)-1,3,5-triazin-2-ylamino)-2-sulfonatophenylazo)-1-ethyl-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-3-pyridinemethanesulfonate

Cas Number:

111850-26-1

Molecular formula:

C24H23ClN8O11S3.xK.yNa

IUPAC Name:

Potassium sodium 5-(5-(4-chloro-6-(4-sulfonatophenylamino)-1,3,5-triazin-2-ylamino)-2-sulfonatophenylazo)-1-ethyl-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-3-pyridinemethanesulfonate

Test animals

Species:

rat

Strain:

other: Wistar KFM-Han. SPF

Administration / exposure

Type of coverage:

occlusive

Vehicle:

other: Dest. Wasser + 4 % CMC-Na-Salz

Duration of exposure:

24h

Doses:

Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Other findings:

Colouration of the skin surface.
In addition, the female rats exhibited erythema, scaling and a weight loss during the observation period. All of the above-mentioned symptoms disappeared at the end of the observation period.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

No death was observed after the application. Therefore, the test substance is not classified for acute dermal toxicity.