Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-003-2 | CAS number: 130-95-0
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: There are no details on the method available. It is a case report.
Data source
Reference
- Reference Type:
- publication
- Title:
- Quinine Sensitivity.
- Author:
- Calnan, C. D. and Caron, G. A.
- Year:
- 1 961
- Bibliographic source:
- Br Med J. 2(5269): 1750–1752
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- It is an experiential report.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Quinine
- EC Number:
- 205-003-2
- EC Name:
- Quinine
- Cas Number:
- 130-95-0
- Molecular formula:
- C20H24N2O2
- IUPAC Name:
- quinine
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Quinine
Constituent 1
Method
- Type of population:
- general
- Route of exposure:
- dermal
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Quinine, even in high concentration, has no irritant or direct toxic action on the skin.
- Executive summary:
In the experiential report of the Department of Dermatology, Royal Free Hospital, London published by Calnan, 1961 the skin irritation and skin sensitisation of quinine was described. A variety of dermatoses have been described in patients taking quinine systemically, and contact dermatitis follow the topical application of quinine. These eruptions are thought to be based on an allergic process. Quinine, even in high concentration, has no irritant or direct toxic action on the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
