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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to the Limit test described in OECD TG403. Restriction: purity of TS not reported; concentration analytically not verified, no data on clinical signs or necropsy.

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List V.
Author:
Smyth HF, Carpenter CP, Weil CS, Pozzani U
Year:
1954
Bibliographic source:
Arch Ind Hyg Occ Med 10: 61-68

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
no
Principles of method if other than guideline:
Toxic effects in rats after inhalation exposure for 4 h
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyl vinyl ether
EC Number:
203-860-7
EC Name:
Butyl vinyl ether
Cas Number:
111-34-2
Molecular formula:
C6H12O
IUPAC Name:
1-(ethenyloxy)butane
Details on test material:
butyl vinyl ether, no further data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
Male and female Carworth-Wistar rats were used, 90 to 120 g in weight. Animals were kept on complete diet.

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: air
Details on inhalation exposure:
Metered atmospheres were generated by using pumps which delivered known amounts of TS to a stream of air. Concentrations are nominal, but not analytically verified; no further details
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Concentrations:
8000 or 16000 ppm corresponding to 33.3 or 66.6 mg/L
No. of animals per sex per dose:
6 rats
Details on study design:
Groups of 6 male or female rats were used. Mortalities noted during the 14-day observation period. Effect levels related to male and female rats combined.

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LC0
Effect level:
8 000 ppm
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: (33.3 mg/L) 0 out of 6 rats died
Sex:
male/female
Dose descriptor:
LC100
Effect level:
16 000 ppm
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: (66.6 mg/L) 6 out of 6 rats died
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 33.3 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: Recommended limit concentration according to OECD TG403 is 5 mg/L
Mortality:
no further details
Clinical signs:
other: no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Conclusions:
No mortality was noted (0/6 animals died) in male and female Wistar rats following exposure to 8000 ppm (=33.3 mg/L) for 4 hours and a post exposure observation period of 14 days. However, a dose level of 16000 ppm (66.6 mg/L) for 4 h killed all 6 rats.
The LC50 (4) in rats is >33.3 mg/L (Limit dose according to OECD TG403 ist 5 mg/L).