Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
June 2014
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
Humic acids and fulvic acids extracted from leonardite, reaction product with formaldehyde, potassium hydrogen sulfite, sodium hydrogen sulfite and potassium hydroxide
Molecular formula:
NA, macromolecular compound
IUPAC Name:
Humic acids and fulvic acids extracted from leonardite, reaction product with formaldehyde, potassium hydrogen sulfite, sodium hydrogen sulfite and potassium hydroxide
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Study design

Analytical method:
photometric method

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
-0.96
Temp.:
20 °C
pH:
1

Any other information on results incl. tables

The partition coefficient (Pow) for each individual determination, the means for each set of test conditions, and the overall mean and standard deviation are shown below.

Sample number

Volume ratio (octanol/water)

Partition coefficient (Pow)

log(Pow)

1

10:1

0.111

-0.95

2

10:1

0.111

-0.95

1

20:1

0.113

-0.95

2

20:1

0.113

-0.95

1

5:1

0.108

-0.97

2

5:1

0.107

-0.97

Average

10:1

0.111

-0.95

Average

20:1

0.113

-0.95

Average

5:1

0.107

-0.97

Overall average± standard deviation

 

0.111 ± 0.003

-0.96

Applicant's summary and conclusion

Conclusions:
The partition coefficient of the test substance was determined according to EU Method A.8; The shake-flask method.
 
Results:
Partition coefficient (Pow):0.111 ± 0.003 (overall average± standard deviation)
log(Pow):-0.96

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