Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Referenceopen allclose all

Reference Type:
other: Predicted data
Title:
No information
Author:
Gedeon Richter Plc. Health and Safety Department
Year:
2015
Bibliographic source:
QSAR Toolbox 3.1.0.21
Reference Type:
other: Predicted data
Title:
No information
Author:
Gedeon Richter Plc. Health and Safety Department
Year:
2015
Bibliographic source:
VegaNIC - Vega Non - Interactive Client - version 1.0.8
Reference Type:
other: Predicted data
Title:
No information
Author:
Gedeon Richter Plc. Health and Safety Department
Year:
2015
Bibliographic source:
T.E.S.T. version 4.1
Reference Type:
other: Predicted data
Title:
No information
Author:
Gedeon Richter Plc. Health and Safety Department
Year:
2015
Bibliographic source:
ChemProp - QSAR 6 Public OSIRIS Edition

Materials and methods

Test guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.39 mg/L
Nominal / measured:
estimated

Any other information on results incl. tables

Software Database / Method Endpoint Test duration Species Predicted value
QSAR Toolbox Aquatic OASIS LC50 96 h Pimephales promales 0.739 mg/l
VegaNIC N.A. LC50 96 h Fathead minnow 0.58 mg/l
T.E.S.T. Consensus method LC50 96 h Fathead minnow 0.49 mg/l
T.E.S.T. Hiearchical Clustering Method LC50 96 h Fathead minnow 0.48 mg/l
T.E.S.T. Group Contribution Method LC50 96 h Fathead minnow 0.3 mg/l
T.E.S.T. FDA method LC50 96 h Fathead minnow 0.11 mg/l
ChemProp Martin and Young model LC50 96 h Fathead minnow 0.04 mg/l
Inferental result         0.39 mg/l

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modells: QSAR Toolbox, VegaNIC, T.E.S.T., ChemProp the predicted values indicated that gonol is hazardous to fishes. The result meets the requirement of Aquatic Acute Category 1.