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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Well conducted study, but insufficient for assessment (only 1% dilution tested, reading time points only 2, 6 and 24 hours in the absence of any irritation reaction, only 2 animals tested).

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
yes
Remarks:
only 1% dilution tested, reading time points only 2, 6 and 24 hours in the absence of any irritation reaction, only 2 animals tested
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Octyl octanoate
EC Number:
218-980-5
EC Name:
Octyl octanoate
Cas Number:
2306-88-9
Molecular formula:
C16H32O2
IUPAC Name:
octyl octanoate
Details on test material:
- Name of test material (as cited in study report): only trade name given
- Analytical purity: not reported

Test animals / tissue source

Species:
rabbit
Strain:
other: New Zealand

Test system

Vehicle:
other:
Controls:
other: untreated eye served as control
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
- Concentration (if solution): 1%

Duration of treatment / exposure:
single treatment
Observation period (in vivo):
24 h
Reading time points: 2, 6 and 24 hours
Number of animals or in vitro replicates:
2
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no

SCORING SYSTEM: Draize scoring system

TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Remarks:
out of all 2 animals
Time point:
other: 24 h
Score:
0
Max. score:
4
Reversibility:
other: reversibility: not applicable
Irritation parameter:
iris score
Basis:
mean
Remarks:
out of all 2 animals
Time point:
other: 24 h
Score:
0
Max. score:
2
Reversibility:
other: reversibility: not applicable
Irritation parameter:
conjunctivae score
Basis:
mean
Remarks:
out of all 2 animals
Time point:
other: 24 h
Score:
0
Max. score:
3
Reversibility:
other: reversibility: not applicable
Irritation parameter:
chemosis score
Basis:
mean
Remarks:
out of all 2 animals
Time point:
other: 24 h
Score:
0
Max. score:
4
Reversibility:
other: reversibility: not applicable

Applicant's summary and conclusion