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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract

Data source

Reference
Reference Type:
publication
Title:
NTP Report on the Assessment fo Contact Hypersensitivity to 1-Ethyl-3-Methylimidazolium Chloride in Female BALB/c Mice
Author:
NTP-National Toxicology Program
Year:
2010
Bibliographic source:
NTP Report Number I07018

Materials and methods

Principles of method if other than guideline:
Combined local lymph node assay (LLNA) and irritancy assay (IRR)
GLP compliance:
not specified
Type of study:
mouse local lymph node assay (LLNA)

Test material

Reference
Name:
Unnamed
Type:
Constituent

In vivo test system

Test animals

Species:
mouse
Strain:
Balb/c
Sex:
female

Study design: in vivo (LLNA)

Vehicle:
acetone/olive oil (4:1 v/v)
Concentration:
6.25; 12.5; 25 and 50 %

Results and discussion

Any other information on results incl. tables

In teh LLNA, EMI at concentrations of 6.25 - 50% did not induce significant increases in lymph nde cell proliferation when compared to the vehicle control. In addition, EMI was not an irritant at concentrations up to 50%, as demonstrated by a lack of effect on ear thickness at 24 hr following the last dermal exposure.

Applicant's summary and conclusion