Registration Dossier
Registration Dossier
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EC number: 810-258-3 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Both the oral and dermal toxicity of the registered substance were determined to be greater than 2000 mg.kg bw. As such, the registered substance is not considered classifiable for acute toxicity according to the EC regulations 1272/2008 and subsequent regulations on classification, labelling and packaging of substances and mixtures.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- This study is a guideline study with a Klimisch score of 1 (reliable withiout restriction)
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The registered substance was not lethal by the dermal route of administration in male and female rats at a dose level of 2000 mg/kg. The test item did not cause any systemic toxic effect, and no specific organs for toxicity were identified. The test item was slightly irritating to the exposed skin, however the irritation was reversible.
The registered substance was not lethal by the oral route of administration in female rats at a dose level of 2000 mg/kg. The test item did not cause any systemic toxic effect, and no specific organs for toxicity were identified.
No acute toxicity studies by any other route are available for the registered substance.
Justification for selection of acute toxicity – oral endpoint
Only study available which also meets the appropriate test guideline. Note: The actual value of LD50 for this study is greater than 2000 mg/kg bw
Justification for selection of acute toxicity – inhalation endpoint
See waiver for acute inhalation endpoint in section7.2.2.
Justification for selection of acute toxicity – dermal endpoint
Only study available which also meets guidelines. Note: Actual value of LD50 for this study is greater than 2000 mg/kg bw
Justification for classification or non-classification
Based on the results of the oral and dermal studies according to the EC regulations 1272/2008 and subsequent regulations on classification, labelling and packaging of substances and mixtures, the registered substance does not require classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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