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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
The 7th of June, 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
adopted 27.07.95
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
photometric method
Type:
Pow
Partition coefficient:
ca. 0.013
Temp.:
20 °C
pH:
6.05
Type:
log Pow
Partition coefficient:
ca. -2.053
Temp.:
20 °C
pH:
6.05
Details on results:
A first scan of the solutions was performed in the range 190 – 800 nm to choose the best wavelength peak for the quantitative measurements. In the case of the test item: lambda= 416 nm.Concentration of the n-octanol phase was very low: even applying direct measurement of the n-octanol phase, absorbance values were far below the lower limit of the spectrometrer's sensibility.
Conclusions:
log Pow = - 2.0528
Executive summary:

Method

Partition coefficient was determined by OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method), adopted 27.05.95.

n- octanol and double distilled water were pre saturated: enough quantity of double distilled water was mixed with n-octanol at room temperature and kept under agitation during 24 hours, then allowing phase separation. Analogous procedure was followed for n-octanol with addition of double distilled water.

Approximately exactly 0.1 g test sample was weighed and dissolved with double distilled water saturated in n-octanol to 250 ml in a volumetric flask (mother solution). pH was recorded.

Results

The average Pow measured is 0.012691 at pH of 6.05, the average log Pow measured is - 2.0528 at 20 °C.

Description of key information

logKow = - 2.0528 

Key value for chemical safety assessment

Log Kow (Log Pow):
-2.053
at the temperature of:
20 °C

Additional information

Partition coefficient was determined by OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method), adopted 27.05.95.

n- octanol and double distilled water were pre saturated: enough quantity of double distilled water was mixed with n-octanol at room temperature and kept under agitation during 24 hours, then allowing phase separation. Analogous procedure was followed for n-octanol with addition of double distilled water.

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