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EC number: 234-465-8 | CAS number: 12005-21-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-12-09 to 2010-12-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- yes
Test material
- Reference substance name:
- Pentaaluminium triyttrium dodecaoxide
- EC Number:
- 234-465-8
- EC Name:
- Pentaaluminium triyttrium dodecaoxide
- Cas Number:
- 12005-21-9
- Molecular formula:
- Al5O12Y3
- IUPAC Name:
- pentaaluminium triyttrium dodecaoxide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): L181
- Substance type: inorganic
- Physical state: solid
- Analytical purity: presumably > 99.9 %
- Lot/batch No.: VS 503G/10
- Expiration date of the lot/batch: not applicable
- Stability under test conditions: stable
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, 97633 Sulzfeld, Germany
- Age at study initiation: males 8 - 9 weeks, females 14 weeks
- Weight at study initiation (administration): males 248 - 252 g, females 208-230 g
- Housing: full barrier in an air-conditioned room
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3 °C
- Humidity (%): 55 +/- 10 %
- Air changes (per hr): 10 12 / 12
- Photoperiod (hrs dark / hrs light):
IN-LIFE DATES: From: 2010-012-09 To: 2012-12-29
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Remarks:
- Aqua ad injectionem (Berlin Chemie, lot no. 01954, expiry date 04/2013)
- Details on dermal exposure:
- TEST SITE
- % coverage: ca. 10
- Type of wrap if used: additional dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes; aqua ad injecionem
- Time after start of exposure: 24 h
TEST MATERIAL
- Constant volume or concentration used: yes
- For solids, paste formed: moisted with water
VEHICLE
- Lot/batch no. (if required): Berlin Chemie, lot no. 01954, expiry date 04/2013 - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5 each
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weighing in day 1 (prior to application), day 8, day 15. A careful clinical observation was made several times on the day of dosing (at least during the first 30 minutes and with special attention given during the first 4 hours post dose). thereafter, the animals were observed for clinical signs once daily until the end of the observation period.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed.
- Clinical signs:
- Nasal discharge 1h, 2 h, 3 h and 4 h post dose which is not considered to be test-item related.
- Body weight:
- body weight [g] and body weight gain [%]
Animal No. / Sex day 1 day 8 day 15 % day 1 -15
21 / M 252 268 300 19
22 / M 252 279 314 25
23 / M 251 270 305 22
24 / M 248 272 300 21
25 / M 250 274 308 23
11 / F 227 223 228 0.4
12 / F 220 217 230 4.5
13 / F 208 206 210 1
14 / F 230 240 249 8
15 / F 220 217 229 4 - Gross pathology:
- With the exception of acute injection of blood vessels in the abdominal region, which is due to the euthanasia injection, no specific gross pathological changes were recorded for any animal.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- After an application period of 24 hours followed by an observation period of 14 days, no mortality and other adverse effects were observed. L181is non-toxic via the dermal route according to CLP
- Executive summary:
The acute dermal toxicity of L181 was assessed in a GLP limit test according to OECD 402. 2000 mg/kg body weight of the test item were applied on the skin of Wistar rats (5 males, 5 females). The exposure period was 24 hours followed by an observation period of 14 days.
Erythema grade1 were observed in 2 of 5 female animals. Desquamination was observed in 1 of 5 female animals. Eschar was observed in 3 of 5 female animals. Scratches were observed in 3 of 5 female and 2 of 5 male animals. All sings of irritation were reversible within the observation period.
No mortalities and no treatment-related other adverse effects were observed.
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