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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

BCF values calculated were:  23, 39.1 and 42 L/kg ww. 

Key value for chemical safety assessment

BCF (aquatic species):
42 L/kg ww

Additional information

The bioaccumulation in fish of the test substance was appraised with two QSARs (CAESAR and Meylan) included in two softwares (BCFBAF and Vega NIC). CAESAR QSAR used exclusively the internally calculated log Kow value (3.17). Even if the evaluation is reliable based on its internal criteria, the BCF value (23 L/kg whole body ww) appraised with this QSAR cannot be used for the Chemical Safety Assessment (CSA), as the log P estimated is too different (3.17) of the log Kow measured (5). In the Meylan QSAR, either the measured (5) or the calculated (5.04) log Kow values were used to appraise the BCF value. Both log Kow values were quite similar. Therefore, the highest BCF value (42 L/kg whole body ww) was used for the CSA.

BCF values calculated by Meylan QSAR (39.1 and 42 L/kg ww) show a low bioaccumulation potential of the test substance.

Therefore, as no bioaccumulation hazard was identified with alternative methods and to comply with article 25 of REACH regulation which states that “In order to avoid animal testing, testing on vertebrate animals for the purposes of this Regulation shall be undertaken only as a last resort.”, no experimental study on fish is necessary to estimate the bioaccumulation potential of the test substance.