Registration Dossier
Registration Dossier
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EC number: 805-711-7 | CAS number: 1006899-79-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance EPO is an organic liquid. It is a UVCB produced by epoxidation of palm oil.
The molecular weight of EPO is > 500 g/mol. The substance has a calculated octanol/water partition coefficient value (log Pow) of >10 and water solubility of <0.01 mg/L at 30°C. Based on these characteristics, oral absorption via the lymphatic system is likely. The in vivo read-across data from ESBO indicate no adverse effects if oral absorption occurs (acute oral LD50 of >5,000 mg/kg , 2 year chronic study NOEL (male) of 1000 mg/kg bw/day and NOEL (female) of 1400 mg/kg bw/day, pre-natal developmental toxicity maternal/developmental NOAEL of 1000 mg/kg bw/day.
The in vivo read-across data from ESBO data indicates is poorly absorbed via the dermal route (slightly irritating in the in vivo skin irritation study in rabbits and non-sensitising in Guinea pig maximisation test). Any significant dermal absorption is unlikely.
No inhalational toxicity data is available however absorption via inhalation is unlikely due to the low vapour pressure of EPO (0.5 kPa at 25°C).
Similar to ESBO, EPO is expected to be broken down in the gastrointestinal tract by esterases (pancreatic lipase) to epoxidised fatty acids and glycerol. After metabolism, a wide distribution is expected. Breakdown products of EPO are expected to be excreted in the urine.
For chemical safety assessment purposes, the absorption rates of 50% (oral), 10% (dermal) and 100% (inhalation) are accepted.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
A full toxicokinetic report is attached.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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