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Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
The study did not meet current guideline requirements for repeated dose toxicity.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1968

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trimethoxysilane
EC Number:
219-637-2
EC Name:
Trimethoxysilane
Cas Number:
2487-90-3
Molecular formula:
C3H10O3Si
IUPAC Name:
Trimethoxysilane

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
two weeks
Frequency of treatment:
5 days/weeek
Doses / concentrations
Remarks:
Doses / Concentrations:
0.2 ml/kg bw
Basis:
actual ingested
No. of animals per sex per dose:
5/sex/group
Control animals:
no
Details on study design:
Test material was administered as a single dose intubation using calibrated syringe and a suitable catheter. Material was administered in the undiluted form (0.2 ml/kg) to 5 male and 5 female rats. 

Examinations

Sacrifice and pathology:
Pathological observation was made on representative animals.

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Mortality:
mortality observed, treatment-related
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Details on results:
Oral administration of 0.2 ml/kg trimethoxysilane caused 5 deaths and abnormal kidney pathology.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
In a pre-GLP, non-guideline repeated dose toxicity study (reliability score 4) 0.2 ml/kg bw undiluted trimethoxysilane was administered by oral gavage five days/week for two weeks, to five male and five female rats. Pathological examinations were conducted on representative animals. There were five deaths and abnormal kidney pathology.