Registration Dossier

Toxicological information

Endpoint summary

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Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Justification for classification or non-classification

NBPT produced evidence of skin sensitization in 13% of the animals (2 of 15) at the challenge reading.  While the number of animals studied is lower than the 20 recommended by OECD Guideline 406, the study is well documented and reliable. It is highly unlikely that additional animals would increase the number of animals with positive responses to 30% or greater.  Based upon this information, the criteria for classification as a dermal sensitizer according to CLP are not met.