Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
review article or handbook
Title:
Final Report on the safety Assessment of Methenamine
Author:
Zondlo, M.
Year:
1992
Bibliographic source:
Journal of the american college of toxicology, Volume 11, Number 4, 1992

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Review article only. No guideline indicated. For details on method see IUCLID5 materials and methods section.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methenamine
EC Number:
202-905-8
EC Name:
Methenamine
Cas Number:
100-97-0
Molecular formula:
C6H12N4
IUPAC Name:
1,3,5,7-tetraazatricyclo[3.3.1.1~3,7~]decane
Details on test material:
not indicated.

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
6 male animals

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact and abraded
Vehicle:
water
Controls:
not specified
Amount / concentration applied:
0.5 mL of a 0.20 % solution in water.
Duration of treatment / exposure:
24 h
Observation period:
72 h
Number of animals:
6 male animals

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24, 48, 72 h
Score:
0
Max. score:
4
Reversibility:
no data
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24, 48, 72 h
Score:
0
Max. score:
4
Reversibility:
no data
Irritant / corrosive response data:
no responses detected
Other effects:
no responses detected

Any other information on results incl. tables

no responses detected

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
Methenamine is not irritating to the rabbit skin.
Executive summary:

Methenamine is not irritating to the rabbit skin.