Registration Dossier
Registration Dossier
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EC number: 202-905-8 | CAS number: 100-97-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the safety Assessment of Methenamine
- Author:
- Zondlo, M.
- Year:
- 1 992
- Bibliographic source:
- Journal of the american college of toxicology, Volume 11, Number 4, 1992
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Review article only. No guideline indicated. For details on method see IUCLID5 materials and methods section.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methenamine
- EC Number:
- 202-905-8
- EC Name:
- Methenamine
- Cas Number:
- 100-97-0
- Molecular formula:
- C6H12N4
- IUPAC Name:
- 1,3,5,7-tetraazatricyclo[3.3.1.1³,⁷]decane
- Details on test material:
- not indicated.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- 6 male animals
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL of a 0.20 % solution in water.
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6 male animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- no data
- Irritant / corrosive response data:
- no responses detected
- Other effects:
- no responses detected
Any other information on results incl. tables
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Methenamine is not irritating to the rabbit skin.
- Executive summary:
- Methenamine is not irritating to the rabbit skin.
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