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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
genetic toxicity in vitro
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Review publication

Data source

Reference
Reference Type:
review article or handbook
Title:
Safety assessment of glycolic acid, ammonium, calcium, potassium, and sodium glycolate, methyl, ethyl, ptopyl, and butyl glycolate, and lactic acid, ammonium calcium, potassium, sodium, and TEA-lactate, methyl, ethyl, isopropyl, and butyl lactate, and
Author:
Andersen, F.A.
Year:
1997
Bibliographic source:
Cosmetic Ingredients Review, final report. International Journal of Toxicology, Vol.17, Suppl.1.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
other
GLP compliance:
no
Type of assay:
other: Review on several mutagenicity studies with lactic acid and some lactates

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Species / strain
Species / strain:
other: various
Metabolic activation:
with and without
Test concentrations with justification for top dose:
Various

Results and discussion

Test results
Metabolic activation:
with and without
Genotoxicity:
negative
Remarks on result:
other:
Remarks:
Migrated from field 'Test system'.

Any other information on results incl. tables

The results of 11 studies are reviewed.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

Lactic acid is considered not genotoxic.