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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically accepted calculation method

Data source

Reference
Reference Type:
other: estimation software
Title:
Unnamed
Year:
2000

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: REACH guidance on QSAR R.6, May 2008
Deviations:
not applicable
Principles of method if other than guideline:
The computer program ECOSAR (v1.00) by US-EPA is used for this estimation. ECOSAR is a scientifically accepted calculation method for organic chemicals; it estimates the toxicity of chemicals discharged to water and predicts beside the acute (short-term) toxicity also the chronic (long-term or delayed) toxicity of a chemical.
GLP compliance:
no
Remarks:
not applicable

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
SMILES notation: COC(=O)CCC1=CC(=C(O)C(=C1)N1N=C2C=CC=CC2=N1)C(C)(C)C

Sampling and analysis

Analytical monitoring:
not required

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
other: Green algae; detailed species not reported

Study design

Test type:
other: calculation
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Test conditions

Reference substance (positive control):
not required

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
1.051 mg/L
Nominal / measured:
estimated
Conc. based on:
not specified
Basis for effect:
growth rate
Remarks on result:
other: no algal cell growth inhibition up to its limit of solubility in water
Details on results:
Due to its very low water solubility the substance may not be soluble enough to measure this predicted effect. Further, as the logKow is greater than 5 and the EC50 exceeds the water solubility by factor 10 or more, no effects at saturation are predicted.

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Conclusions:
EC50 for green algae (96h) = 1.051 mg/L, but the substance may not be soluble enough to measure this predicted effect.
Executive summary:

The short-term toxicity value (acute) of the substance of interest for green algae was determined by calculation. This calculation was performed by the computer program form US-EPA (EPIWIN software ECOSAR v1.00); result: EC50(96 h) for green algae = 1.051 mg/L.

Nevertheless, the water solubility (IUCLID section 4.8) and the logKow (IUCLID section 4.7) of a chemical should be compared with the predicted toxicity value derived for a chemical. If the logKow (5.1) is greater than 5 and the LC50 exceeds the measured or predicted maximum water solubility (<0.05 mg/L) by factor 10 or even more then an effect is not expected to occur in a saturated solution.