Calcium-Iron-Silicium-Magnesium-Manganese-Aluminium oxide equivalent

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2001

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study without detailed documentation

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

GLP compliance:

not specified

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Slags, steelmaking, elec. furnace (carbon steel production - EAF C)

IUPAC Name:

Slags, steelmaking, elec. furnace (carbon steel production - EAF C)

Constituent 2

Reference substance name:

Slags, steelmaking, elec. furnace

EC Number:

294-410-9

EC Name:

Slags, steelmaking, elec. furnace

Cas Number:

91722-10-0

Molecular formula:

not applicable

IUPAC Name:

294-410-9

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

animals kept at 12 h light /dark cycle at 22+/-3 °C

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

unchanged (no vehicle)

Doses:

>2000 mg/kg bw

No. of animals per sex per dose:

not reported

Control animals:

not specified

Details on study design:

Observation period of 14 d after incubation

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: no effects on all test animals

Mortality:

no mortality

Clinical signs:

other: no clinical signs

Gross pathology:

none reported

Any other information on results incl. tables

In an acute toxicity test according to OECD TG 401 with Wistar rats, no effect of EAF C was observed in a limit test at 2000 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information not toxic Criteria used for interpretation of results: EU

Conclusions:

EAF C rat LD50 >2000 mg/kg bw

Executive summary:

To examine the oral toxicity of slags, steelmaking, converter (BOS), a test was performed following OECD guideline 401 in Wistar rats. Fine-ground BOS was dosed at 2 g/kg bw (body weight). After dosing, the animals were observed for a post exposure period of 14 days. The LD₅₀ was > 2000 mg/kg bw.

Slags, steelmaking, converter (BOS) are not toxic via the oral route, and do not need to be classified as oral toxicants. Neither a signal word nor a hazard statement is required.