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EC number: 500-107-7 | CAS number: 40039-93-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05/04/2012-17/05/2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP comparable to OECD guideline
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7860 (Water Solubility Generator Column Method)
- Principles of method if other than guideline:
- /
- GLP compliance:
- yes
- Type of method:
- column elution method
- Remarks:
- as modified by use of a generator column apparatus
- Water solubility:
- 33.9 µg/L
- Temp.:
- 20 °C
- pH:
- 6.58
- Remarks on result:
- other: For component n=0
- Water solubility:
- > 1 µg/L
- Temp.:
- 20 °C
- pH:
- 6.58
- Remarks on result:
- other: For component n=1. The overall mean measured water solubility of Brominated Epoxy, based on the secondary component, at 20°C was less than the LOQ (1.00 μg/L)
- Details on results:
- Under the instrumental conditions presented, the mean measured reagent water solubility of Brominated Epoxy, based on the primary component, at 20°C was 30.3 ± 1.3 μg/L (CV = 4.3%, N = 5) at a flow rate of approximately 1.0 mL/min and was 37.5 ± 1.6 μg/L (CV = 4.3%, N = 5) at a flow rate of approximately 0.5 mL/min. The mean measured Brominated Epoxy concentration as a function of flow-rate differed by 21.3%, which was well within the ±30% test criterion. The overall mean measured water solubility of Brominated Epoxy, based on the primary component, at 20°C was 33.9 ± 4.1 μg/L (CV = 12%, N = 10)
The mean measured reagent water solubility of Brominated Epoxy, based on the secondary component, at 20°C was less than the LOQ (1.00 μg/L) at both flow rates. The overall mean measured water solubility of Brominated Epoxy, based on the secondary component, at 20°C was less than the LOQ (1.00 μg/L), respectively. The pH was measured for an aqueous sample collected at a flow rate of 1.0 mL/min. The measured pH of reagent water and an aqueous sample was 6.58 and 8.38, respectively. - Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of Brominated Epoxy, based on the primary component, in reagent water at 20°C using the column elution method was determined to be 33.9 ± 4.1 μg/L (CV = 12%, N = 10). - Executive summary:
The water solubility of Brominated Epoxy, based on the primary component, in reagent water at 20°C using the column elution method was determined to be 33.9 ± 4.1 μg/L (CV = 12%, N = 10).
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13/04/2012-07/06/2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP comparable to OECD guideline
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7860 (Water Solubility Generator Column Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Principles of method if other than guideline:
- /
- GLP compliance:
- yes
- Type of method:
- column elution method
- Water solubility:
- 26.4 µg/L
- Temp.:
- 20
- pH:
- 6.47 - 7.64
- Remarks on result:
- other: pH of reagent water: 6.47 and an aqueous sample: 7.64
- Details on results:
- Under the instrumental conditions presented, the mean measured reagent water solubility of F-2200 HM, based on the primary component, at 20°C was 25.8 ± 2.0 μg/L (CV = 7.7%, N = 5) at a flow rate of approximately 1.0 mL/min and was 27.0 ± 0.43 μg/L (CV = 1.6%, N = 5) at a flow rate of approximately 0.5 mL/min (Table 3). The mean measured F-2200 HM concentration as a function of flow-rate differed by 4.4%, which was well within the ±30% test criterion. The overall mean measured water solubility of F-2200 HM, based on the primary component, at 20°C was 26.4 ± 1.5 μg/L (CV = 5.7%, N = 10).
The mean measured reagent water solubility of F-2200 HM, based on the secondary component, at 20°C was less than the LOQ (20.0 μg/L) at both flow rates (Table 3). Note: although two fractions (238C-134-9 and –10) had quantified traces for F-2200 HM as the secondary component similar in calculated concentration to the results from the primary component, in the opinion of the Study Director, this was coincidental due to very low response relative to the baseline. The overall mean measured water solubility of F-2200 HM, based on the secondary component, at 20°C was less than the LOQ (20.0 μg/L).
Representative chromatograms of solubility samples at flow rates of approximately 1.0 and 0.5 mL/min are presented in Figure 7. The pH was measured for an aqueous sample collected at a flow rate of 1.0 mL/min. The measured pH of reagent water and an aqueous sample was 6.47 and 7.64, respectively. - Conclusions:
- Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The water solubility of F-2200 HM, based on the primary component, in reagent water at 20oC using the column elution method was determined to be 26.4 ± 1.5 μg/L (CV = 5.7%, N = 10). - Executive summary:
The water solubility of F-2200 HM, based on the primary component, in reagent water at 20oC using the column elution method was determined to be 26.4 ± 1.5 μg/L (CV = 5.7%, N = 10).
Referenceopen allclose all
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Description of key information
Water solubility of Brominated Epoxy and F-2200
Key value for chemical safety assessment
- Water solubility:
- 33.9 µg/L
- at the temperature of:
- 20 °C
Additional information
n=0 component is the most soluble component while water solubility of components n=1 and n=2 were less than study LOQ. Thus, the water solubility value for n=0 component is taken for assessment.
The water solubility of Brominated Epoxy based on the primary component, in reagent water at 20°C using the column elution method was 33.9 μg/L.
The water solubility of F-2200, based on the primary component, in reagent water at 20°C using the column elution method was 26.4 μg/L.
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