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EC number: 231-130-8 | CAS number: 7440-21-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study well documented, meets general scietific principles, acceptable for accessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of chronic amorphous silica exposure on sequential pulmonary function.
- Author:
- Wilson, R. K., P. M. Stevens, et al.
- Year:
- 1 979
- Bibliographic source:
- J Occup Med.21(6): 399-402.
Materials and methods
- Study type:
- human medical data
- Endpoint addressed:
- repeated dose toxicity: inhalation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Study contained evaluation of serial spirograms, respiratory questionnaires and chest x-ray pictures of 165 workers exposed to precipitated silica for a mean of 8.6 years. Cumulative exposure indexes taking into account the quantity and duration of exposure were created for each individual.
Test material
- Reference substance name:
- precipitated silica
- EC Number:
- 927-048-3
- IUPAC Name:
- precipitated silica
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- no
- Details on study design:
- The medical records of 165 precipitated amorphous silica (PAS) exposed workers in two industrial facilities were evaluated with regard to annual spirometry, chest roentronogram and most recent respiratory questionnaire. Workers were exposed for at least one year to PAS.Demographic data, smoking histories and positive responses to respiratory health questions were obtained from their medical chart. Relationship of symptoms and PAS exposure and symptoms and smoking was evaluated. Chest X-rays pictures were evaluated for pneumoconiosis. Cumulative dust exposure was calculated for each worker by summing monthly dust exposure. Dust exposure estimation was based on measured data. No external control group was included in the study. Statistical analysis was performed: student's t-test, Fisher exact test, linear and multiple regression and analysis of variance.
Results and discussion
- Results:
- No correlation between cumulative exposure and respiratory function measures were seen. Symptoms did not increase with increasing cumulative exposure. No cases of pneumoconiosis were detected. Cough, dyspnea and respiratory function correlated with tobacco smoking.
Applicant's summary and conclusion
- Conclusions:
- No relationship between amorphous silica exposure and respiratory symptoms or decline in respiratory function was seen. No cases of pneumoconiosis were observed.
- Executive summary:
Wilson (1979) reviewed serial spirograms, respiratory questionnaires and chest x-ray pictures of 165 workers exposed to precipitated silica for a mean of 8.6 years. Cumulative exposure indexes taking into account the quantity and duration of exposure were created for each individual. No correlation between the cumulative exposure and respiratory function measures were seen. Neither did the symptoms increase with increasing cumulative exposure. No cases of pneumoconiosis were detected. Cough, dyspnea and respiratory function correlated with tobacco smoking. No external control group were included in the study.
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