Registration Dossier

Administrative data

Description of key information

Two skin and two eye irritation studies were available with limited information. Also one in vitro skin corrosion test was available.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Based on the limited data available it was noted that TEPA induces corrosive effects on both skin and eyes. For comparison, also the studies with TETA are included (read across).


Justification for selection of skin irritation / corrosion endpoint:
No study was selected as more than one study with limited information was available. Together with information from a read across substance, a conclusion regarding skin irritation was drawn.

Justification for selection of eye irritation endpoint:
No study was selected as more than one study with limited information was available. Together with information from a read across substance, a conclusion regarding eye irritation was drawn.

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

Based on the corrosive effects induced by skin and eye application, TEPA should be labeled as corrosive (as is TETA). Based on the in vitro test results, TEPA should be classified as corrosive Cat. 1B.