Registration Dossier

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study did not follow any guideline and was not performed according to GLP. Route is i.p. Limited reporting.

Data source

Reference
Reference Type:
publication
Title:
Neuropharmacological actions of some binuclear lanthanide(III) complexes
Author:
Williams, L.A.D., Howell, R.C. Young, R., Kahwa, I.A.
Year:
2001
Bibliographic source:
Comparative Biochemistry and Physiology Part C 128 119-125

Materials and methods

Test guideline
Qualifier:
no guideline followed

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
TETA was obtained from Shell Chemical Co. (no further details provided)

Test animals

Species:
mouse
Strain:
Swiss
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 10% DMSO in physiological saline
Doses:
20, 40, 60 and 80 mg/kg bw
No. of animals per sex per dose:
10 per group (sex unknown)
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
38.5 mg/kg bw
Based on:
test mat.
95% CL:
31.4 - 45.7

Applicant's summary and conclusion

Conclusions:
The 24-h LD50 via ip injection in mice was 38.5 mg/kg bw
Executive summary:

In an experimental study in mice, also the 24 -h LD50 value of TETA following intraperitoneal injection was evaluated. This value turned out to be 38.5 mg/kg bw with (95%) confidence limits of 31.4 and 45.7 mg/kg bw.