Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1951
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The study was performed pre-GLP and pre-guideline. Limited reporting. No information on the composition or purity of the test substance.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1953
Report Date:
1953

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
Name: Triethylenetetramine
Source: O.J. Manary
Date received: 8-15-51
Radiolabelling:
no

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per group:
no data

Results and discussion

Absorption in different matrices:
The material was not absorbed in acutely toxic amounts.
Conversion factor human vs. animal skin:
no data

Applicant's summary and conclusion

Conclusions:
The material was not absorbed in acutely toxic amounts.
Executive summary:

Through rabbit skin the material was not absorbed in acutely toxic amounts. No further information.