Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: exposure measurements
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Exposure to low molecular polyamines during road paving
Author:
Levin, J.O., Andersson, K., Hallgren, C.
Year:
1994
Bibliographic source:
Ann occup. Hyg., Vol. 38, No 3. pp. 257 264.

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid

Results and discussion

Applicant's summary and conclusion

Executive summary:

Fatty amine wetting agents are used to increase adhesion in bitumen emulsions used in road paving, but commercial fatty amine products are contaminated with low molecular polyamines and alkanol polyamines which are released from the hot bitumen during paving. Polyamines and alkanol polyamines are known to cause eye and respiratory tract irritation and skin sensitization. The exposure of road pavers to ethylenediamine, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, hydroxyethylethylenediamine, hydroxyethyldiethylenetriamine, monoethanolamine and diethanolamine was studied, since most of these compounds were found in the products used. Personal and static air sampling was performed during road paving. A highly sensitive measurement technique utilizing naphthylisothiocyanate-coated sorbents and filters was used. Exposure was found to be in the range <0.02 -0.5 mg m-3, as total concentration of low molecular polyamines and alkanol polyamines. Since the polyamines and alkanol polyamines in question are highly irritating they may contribute to the symptoms experienced by the road pavers.