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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Reference do not give sufficient experimental details: longer exposure time than recommended by OECD 404, 2002; no details on test material, test animals and little information on administration
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1955

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The day before administration the eight albino rabbits were clipped over the entire trunk, care being taken to avoid cutting or abrading the skin. A single dose of 25g antimony trioxide dust incorporated in aqueous methylcellulose paste was applied to the denuded skin. The test site areas were about two-thirds of the animals`torso. They were covered by an impervious membrane (Vinylite). The test item was applied for one week. After exposure local skin reactions and signs of systemic toxicity were examined.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Diantimony trioxide
EC Number:
215-175-0
EC Name:
Diantimony trioxide
Cas Number:
1309-64-4
Molecular formula:
Sb2O3
IUPAC Name:
dioxodistiboxane
Test material form:
not specified

Test animals

Species:
other: albino rabbits
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
occlusive
Preparation of test site:
other: clipped over the entire trunk without cutting the skin
Vehicle:
other: aqueous methylcellulose paste
Controls:
not specified
Amount / concentration applied:





TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 25 g of antimony trioxide dust incorporated in aqueous methylcellulose paste
- Concentration (if solution): not stated


VEHICLE
- Amount(s) applied (volume or weight with unit): not stated
- Concentration (if solution): not stated
- Lot/batch no. (if required): not stated
- Purity:not stated
Duration of treatment / exposure:
one week
Observation period:
not stated
Number of animals:
eight albino rabbits
Details on study design:
TEST SITE
- Area of exposure: The Methylcellulose paste was applied to the intact skin of two-thirds of the animals' torso.
- Type of wrap if used: The area was covered by an impervious membrane (Vinylite).

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
other: Overall assessment
Time point:
other: Not specified
Score:
0
Max. score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No significant local reaction.
Other effects:
No apparent sign of systemic toxicity.

Any other information on results incl. tables

No significant local reaction. No apparent sign of systemic toxicity.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
No significant local reaction.