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Registration Dossier
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EC number: 251-459-0 | CAS number: 33329-35-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-guidleine, non-GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No data.
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N-bis[3-(dimethylamino)propyl]-N',N'-dimethylpropane-1,3-diamine
- EC Number:
- 251-459-0
- EC Name:
- N,N-bis[3-(dimethylamino)propyl]-N',N'-dimethylpropane-1,3-diamine
- Cas Number:
- 33329-35-0
- Molecular formula:
- C15H36N4
- IUPAC Name:
- (3-{bis[3-(dimethylamino)propyl]amino}propyl)dimethylamine
- Test material form:
- gas under pressure: refrigerated liquefied gas
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 ml of undiluted test substance administered to the eye of each animal.
- Duration of treatment / exposure:
- 5 minute exposure and 24-hour exposure
- Observation period (in vivo):
- Observations at 5 mins, 24hours and 48 hours.
30 days recovery. - Number of animals or in vitro replicates:
- 2 groups of 8
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 5 minutes
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 5-minute exposure
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 5 minute and and 24 hour exposures
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 5 minute and and 24 hour exposures
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: 24 hour exposure
- Irritant / corrosive response data:
- The substance is severely corrosive to the eyes of rabbits. Effects were immediate and severe, and irrevesible after a 30-day recovery period.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is severely corrosive to the eyes of rabbits. Effects were immediate and severe, and irrevesible after a 30-day recovery period.
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