Sodium p-cumenesulphonate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

other: Read across from another member of the category

Adequacy of study:

key study

Study period:

April 10 - 24, 1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Ammonium (xylenes and 4-ethylbenzene) sulphonate

EC Number:

943-024-5

IUPAC Name:

Ammonium (xylenes and 4-ethylbenzene) sulphonate

Test animals

Species:

rat

Strain:

other: albino, COX-SD

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS- Source: Lab Supply Company- Age at study initiation: no data- Weight at study initiation: 217 - 240 grams- Fasting period before study: not fasted- Housing:individually in metal, wire-bottomed cages elevated above the droppings- Diet (e.g. ad libitum): ad libitum- Water (e.g. ad libitum): ad libitum- Acclimation period:no dataENVIRONMENTAL CONDITIONS- Temperature (°C): no data- Humidity (%): no data- Air changes (per hr): no data - Photoperiod (hrs dark / hrs light): no data IN-LIFE DATES: From: April 10, 1980 To: April 24, 1980

Administration / exposure

Route of administration:

inhalation: aerosol

Vehicle:

other: unchanged (no vehicle)

No. of animals per sex per dose:

5 males and 5 females; single dose

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days - Frequency of observations and weighing: at regular intervals during the first day and once daily thereafter- Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight,histopathology, other: behavior and stool- Upon removal from the chamber, the animals were cleaned with lukewarm water to remove any test material having accumulated on their coats and dried with toweling. Animals were then placed in individual cages.- Duration of observation period following administration: 14 days (or other?)- Frequency of observations and weighing:- Necropsy of survivors performed: yes/no- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:

Results and discussion

Preliminary study:

none reported

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 6.41 mg/L air (nominal)

Based on:

test mat.

Mortality:

No deaths

Clinical signs:

other: One animal displayed a pronounced case of soft stool on Day 6 an returned to normal in two days. Otherwise no gross signs of test compound induced adverse effects were observed in the remaining nine animals

Body weight:

Slight weight gains in two animals at 7 and 14 days. The body weights for the remaining 8 animals showed gains within limits of expectation.

Gross pathology:

Five animals showed slight mottling or slight to moderate congestion of the lungs. The remaining five showed tissues to be not remarkable

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

LC50 > 6.41 mg/L based on test material

Executive summary:

The acute inhalation toxicity of Ammonium (xylenes and 4-ethylbenzene) sulfonates was assessed following official method OECD 403, Acute Inhalation Toxicity. One animal displayed a pronounced case of soft stool on Day 6 an returned to normal in two days. No gross signs of test compound induced adverse effects were observed in the remaining nine animals, there was no mortality and half of the exposed animals showed only slight to moderate congestion of the lungs.
Slight weight gains in two animals at 7 and 14 days. The body weights for the remaining 8 animals showed gains within  limits of expectation. Five animals showed slight mottling or slight to moderate congestion of the lungs. The remaining animals did not showed remarkable effects.