Registration Dossier
Registration Dossier
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EC number: 248-122-5 | CAS number: 26942-95-0
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Under the experimental conditions, the test substance did not cause phototoxic effects in guinea pigs.
Additional information
In a study performed by Saboureau (1989), the phototoxic potential of 1,2,3-propanetriyl triisooctadecanoate (CAS 26942-95-0) after dermal application and subsequent exposure to UV radiation was assessed. 6 skin areas along the vertebral axis of 10 male guinea pigs measuring 1 cm² were shaved and depilated. 0.02 mL/ cm² test substance was applied to area 1-3, 0.02 mL/ cm² positive control (8-metoxypsoralene) was applied to area 4, while area 5 and 6 were left untreated. 30 minutes after application of the test substance or positive control substance, area 1, 4 and 5 were radiated with UVA; area 2 and 6 were radiated with UVB; and area three was not radiated. Irradiations were performed using Phillips tube TL 20W/09 N for UVA (1603 s, corresponding to 3222.03 mJ/cm² UVA energy and 224.42 mJ/cm² UVB energy) and TL 20W/12 UV for UVB (58 s, corresponding to 16.24 mJ/cm² UVA energy and 58 mJ/cm² UVB energy). The radiation levels were chosen to allow effects at suberythematous levels. The animals were scored for erythema and oedema according to the Draize scoring system 24 hours after treatment. No significant skin reaction was observed on the sites treated with the test material, whether or not these were subsequently exposed to UV radiation. Under the same conditions, the sites treated with the positive control 8-MOP showed major reactions. No further details or scores were given in the study report. The test substance did not cause phototoxic effects under the experimental conditions.
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