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Classification & Labelling & PBT assessment

PBT assessment

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PBT assessment: overall result

PBT status:
the substance is not PBT / vPvB
Justification:

The PBT Assessment is based on the criteria set out in the “Guidance on information requirements and chemical safety assessment, Chapter R.11: PBT Assessment” (ECHA, 2012).

 

Persistence (P) Assessment:

The substance 1,2,3-propanetriyl triisooctadecanoate (CAS 26942-95-0) is not readily biodegradable. Therefore, a persistency of the substance in the environment cannot be excluded.

Bioaccumulation (B) Assessment:

Due to the low water solubility and metabolisation via enzymatic hydrolysis of the substance, a relevant uptake and bioaccumulation in aquatic organisms is not expected. Enzymatic breakdown will initially lead to the free fatty acid and the free alcohol. From literature it is well known, that these hydrolysis products will be metabolised and excreted in fish effectively (Heymann, 1980; Lech & Bend, 1980; Lech & Melancon, 1980; Murphy & Lutenske, 1990). This is supported by the low BCF and BAF values calculated for the substance of 0.89 L/kg ww respectively (BCFBAF v3.01, Arnot-Gobas, including biotransformation, upper trophic). Based on the available information, the substance does not meet the B or vB criteria.

Toxicity (T) Assessment:

1,2,3-propanetriyl triisooctadecanoate (CAS 26942-95-0) is considered to be not toxic. The assessment is based on a chronic toxicity study on Daphnia magna according to OECD 211, determining a NOEC (21 d) > 1 mg/L. Furthermore the substance is not classified for specific target organ toxicity, carcinogenicity, mutagenicity or reproductive and developmental toxicity in mammals. The criteria for “T” based on mammalian effects are therefore not met.